Cannabis in Molecules: Cannabinol (CBN)

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Cannabinol (or CBN) is one of the most prevalent and best studied substance of Cannabis, along with THC and CBD.

In this video you will discover Cannabinol’s multiple uses, from burn management to bone formation and much more.

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References of the studies cited :

Rhee, M. H., Vogel, Z., Barg, J., Bayewitch, M., Levy, R., Hanuš, L., Breur, A. & Mechoulam, R. 1997. Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase. Journal of Medicinal Chemistry, 40, 3228-3233.

Flaubert, B. L. & Kaminsky, N. E. (2000). AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun. J Leukoc Biol, 67, 259-66.

Herring, A. C., Faubert Kaplan, B. L. & Kaminsky, N. E. (2001). Modulation of CREB and NF-κB signal transduction by cannabinol in activated thymocytes. Cellular Signalling, 13, 241-250.

Turner CE, Elsohly MA, Boeren EG (1980). Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod 43: 169–234.

Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (2008). TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28:
6231–6238.

Wilkinson JD, Williamson EM (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci 45: 87–92.

Scutt A, Williamson EM (2007). Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 80: 50–59.

Holland ML, Allen JD, Arnold JC (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol 591: 128–131.

Viola Brugnatelli

Viola Brugnatelli is a Neuroscientist specialised in Cannabinoid circuitry, GPCRs signalling, and neuropharmacology. Her academy and research training let her gain extensive experience on medical cannabis and phytoceuticals both from preclinical as well as clinical perspective. She works as a consultant and speaker at seminars, workshops & tutorials for MDs, Universities and individual patients. She has been raised by the concepts of equality, responsibility and love towards the environment, others and oneself. In her vision, collective human knowledge behold the power for overall improvement of life at all its forms, thus, it should be accessible and shareable. Viola is currently researching therapeutic potentials of terpenes at University College of Dublin, Ireland, and established since 2014 the Science Online Magazine Nature Going Smart.

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