Cannabis suppositories: taking your medicine down under
There are several methods of getting Cannabis into your body. Here I will talk about one of the most efficient methods of Cannabis intake – suppositories.
You are welcome to read further on the heated topic of its absorption in another article: Cannabis suppository bioavailability: YES or NO?
Although it might not be the most practical way of assuming your medicine and some people might have stigmas associated with this particular method, it does have a lot of advantages.
- Different types of suppositories Source: Slideshare.net
Cannabis suppositories: higher bioavailability
Please read our updated article on this regard: Cannabis suppository bioavailability: YES or NO?
Besides taking Cannabis tinctures sublingually, rectal administration is the method with the highest bioavalability: over 60%; When comparing it with other methods of intake (oral 10-20%, smoking 10-15%, vaporisation 33%) we can clearly see that it is very effective.
This is due to the function of tissues present in the lower part of the rectum, which main job is to reupatake any water and usable nutrients that are still present in the faeces.
Less Side effects
One of the reasons Cannabis suppositories are so popular with patients, is that it significantly diminishes the side effects of delta-9-THC, mainly the notorious “high” feeling.
Most patients are really not interested in being high and just want to function as normal people without having the symptoms of their specific disease.
The cannabinoids present in suppositories, when correctly inserted, bypass the liver and go straight into the blood. This prevents the first pass metabolism of cannabinoids. This is important in delta-9-THC rich suppositiries as the first product of first pass metabolism is 11-OH-THC which has been shown to be 4-5 times more psychotropic than non-metabolized delta-9-THC.
Patients can take larger doses and most of them don’t even fell the high after taking them for some time.
Longer beneficial effects
The beneficial effects of the Cannabis constituents are felt longer and the doses can be lower due to the efficiency of this method of delivery.
It is also important to distinguish the difference between beneficial effects and the “high” feeling. Most people correlate the two, but the high feeling is just one of the (side)effects of cannabis and usually not the most important one.
You can prepare the suppositories at home by adding organic cocoa butter to the cannabis extract in special suppository moulds (be sure to buy the rectal ones as there are also vaginal suppository moulds) and placing them in the fridge.
Take them out of the fridge before insertion, so they do not melt beforehand.
When taking suppositories you should follow some practical guidelines:
lie on your side with your knees bent (90 degree angle)
insert the suppository 2,5 cm into the rectum past the anal sphincter. If you insert it deeper it will be partially absorbed by veins going to the liver
tighten your lower rectum muscles so the medicine doesn’t drip out
stay in this position for 10-15 minutes
As you can see, Cannabis suppositories are an efficient method of bringing Cannabis to your body with less side effects, a higher bioavalability and a longer positive effect duration.
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Brenneisen, R., Egli, A., Elsohly, M. A., Henn, V. and others. (1996). The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. Int.J.Clin.Pharmacol.Ther. 34: 446-452
Perlin, E., Smith, C. G., Nichols, A. I., Almirez, R. and others. (1985). Disposition and bioavailability of various formulations of tetrahydrocannabinol in the rhesus monkey. J.Pharm.Sci. 74: 171-174.