Cannabis in molecole: CBD (Cannabidiolo)

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Che cos’è il cannabidiolo (CBD) e a cosa serve?

Il cannabidiolo funziona come antagonista indiretto del più celebre THC.
Cannabidiolo agisce anche sui recettori 5-HT (1A) (serotonina) come agonista, un’azione per la quale provvede le sue proprietà antidepressive, ansiolitiche e neuroprotettive.
CBD agisce inoltre come modulatore dei recettori oppioidi mu e delta, per I quali svolge le sue azioni analgesiche.

In questo video vengono riassunte alcune tra le sue molteplici funzioni. Se vuoi approfondire l’argomento, ti suggeriamo di leggere questo articolo sulle sue proprietà anti-cancro.

Buona visione!

 

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Referenze:

Rhee, M. H., Vogel, Z., Barg, J., Bayewitch, M., Levy, R., Hanuš, L., Breur, A. & Mechoulam, R. 1997. Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase. Journal of Medicinal Chemistry, 40, 3228-3233.

Flaubert, B. L. & Kaminsky, N. E. (2000). AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun. J Leukoc Biol, 67, 259-66.

Herring, A. C., Faubert Kaplan, B. L. & Kaminsky, N. E. (2001). Modulation of CREB and NF-κB signal transduction by cannabinol in activated thymocytes. Cellular Signalling, 13, 241-250.

Turner CE, Elsohly MA, Boeren EG (1980). Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod 43: 169–234.

Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (2008). TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28:6231–6238.

Wilkinson JD, Williamson EM (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci 45: 87–92.

Scutt A, Williamson EM (2007). Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 80: 50–59.

Holland ML, Allen JD, Arnold JC (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol 591: 128–131.

Viola Brugnatelli

Viola Brugnatelli is a Neuroscientist specialised in Cannabinoid circuitry & GPCRs signalling. Her academy and research training let her gain extensive experience on medical cannabis and terpenes both from preclinical as well as clinical perspective.
In her vision, collective human knowledge behold the power for overall improvement of life, thus, it should be accessible and shareable.
Viola is Founder of the science online magazine Nature Going Smart, and works as a consultant for companies & individual patients, as a speaker at seminars and workshops and as a lecturer in a CME course on Medical Cannabis in Italy, at the University of Padua.

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