CBD: an effective agent against metastasis

CBD metastasis
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Sometimes, when we fear for our life, or that of our dear ones, it is too scary to question the unquestionable chemo-radiation-surgery formula.

I understand if you feel like this. It is the least appropriate moment for experimenting something that strays you away from what traditional medicine has been prescribing you. (This is, unless you live in a Country were Medical Cannabis is a reality).

I created Nature Going Smart with one intent: to provide scientific evidence for anyone to understand fully the mechanisms behind our choices.

I strongly believe that for most of us, understanding the process behind certain recommendations, could mean the difference between “reading some health-claims on the internet” and taking full responsibility for our health (and that of the Planet).

If you are still skeptical on this “Cannabis kills cancer” idea, or simply willing to deepen your understanding on how this safe medication works, this article is for you. (As well as this video: “Does Cannabis Oil treat cancer?”)

How Cannabidiol (CBD) fights aggressive breast cancer cells

A metastatic cancer is the condition during which cancerous cells invade a tissue not directly linked to the initial site of tumorigenesis, thus forming a secondary tumor.
Despite all currently available treatments, once clinically apparent metastases develop, breast cancer is most often incurable.

Clearly, effective and non-toxic therapies are urgently required; a growing body of evidence is finding that the unique properties of Cannabidiol (CBD), a non-psychotropic component of the plant Cannabis Sativa, are very useful for inhibiting proliferation of metastatic breast cancer cells.

Can metastasis be inhibited?

Understanding the genetic changes required for breast cancer to develop and invade other tissues with metastasis is still quite tricky. However, it has been found that expression of a gene called Id-1, initiates cell de-differentiation, uncontrolled proliferation and invasion which are the final and fatal steps during
cancer progression.

The Id family of helix-loop-helix proteins control cellular processes related to tumor progression such as cell growth and differentiation. In order to establish the association between Id-1 and metastasis, the Id-1 gene was over-expressed in breast cancer cells under laboratory conditions. This resulted in overactive Id proteins and statistically significant increase in metastasis of the lungs.

This net correlation between high levels of Id-1 proteins and number of metastasizing cancers prompted the research group at California Pacific Medical Center to investigate the effects of reducing Id-1.

They did so by reversing the strategy with a technique known as antisense technology, which is used to block expression of genes.

They found that down-regulation of Id-1 led to a significant reduction in breast cancer cell proliferation and invasiveness both in vitro, as well as reduction of development metastasis in vivo (in mice).
The research group then screened a large number of chemicals to find the most effective inhibitor of Id-1, and found that the cannabinoid CBD was by far the most effective as well as safest compound testedfor inhibiting human breast cancer cell proliferation and invasiveness.

This is an important discovery highlighting the mechanism by which the compound CBD produces anti-metastatic activity and fights breast cancer.

There is an urgent clinical need!

Currently, available therapeutic strategies for treating the metastatic stage of cancer progression are highly toxic, show poor efficacy and are nonspecific, meaning that molecular mechanisms regulatingthe development of aggressive cancers are left untargeted.

It has been shown in a variety of cancer studies that cannabinoids such as delta-9-tetrahydrocannabinol (THC) act as tumor inhibitors via activation of the cannabinoid receptors CB1 and CB2. However, new evidence also shows that the cannabinoid constituent CBD, has negligible affinity for CB1 and CB2 receptors and yet it also possesses considerable antitumor effects.

This suggests that it is likely there are other mechanisms by which cannabinoids may be fighting tumor growth with.

Plant cannabinoids are stable compounds with low toxicity profiles that are well tolerated by animals and humans during chronic administration. The low affinity of CBD for the aforementioned classic cannabinoid receptors CB1 and CB2, makes this compound not only safe but also devoid of the potentially problematic psychotropic effects found in THC.

Scientists from the Research Institute of San Francisco, who first elucidated this model back in 2007, believe that “reducing Id-1 expression with cannabinoids could also provide a therapeutic strategy forthe treatment of additional aggressive cancers because Id-1 expression was found to be upregulated during the progression of almost all types of solid tumors investigated”, confirming yet again the urgency of updating research-clinician relationship in regards of medical cannabis.

How to start a CBD therapy

CBD Strains

 

CBD oil preparations low in THC are a good way for patients to start medicating with cannabinoid therapy.

Amongst the commercially available CBD oils, the mean average contents are a mere 0.173% THC while providing levels of CBD measuring at > 3%, which ensures safe consumption free of significant psychoactive effects.
Oils with these kinds of high CBD cannabinoid ratios cannot be made from just common strains of cannabis, they need to be made from specifically CBD-rich strains.

For patients concerned with side effects from THC, CBD-rich strains will offer the most comfortable medication. Strains are considered CBD-rich when the CBD content level 4% or above.

Some currently available selected strains of CBD-rich range between 8 and 12% CBD content.
Popular CBD-rich strains include:

  • Shark Shock (THC content of 6.33% and a CBD content of 7.28%)
  • CBD Nordle (CBD content of 8.97 percent, THC 6.43 %)
  • CBD Medi Haze (CBD 8 %, THC 4%)
  • Harlequin (6% THC, 18% CBD)
  • CBD Skunkhaze (1:1 ratio of THC:CBD, resulting in 5% THC and 5% CBD)

Due to growing conditions and other factors such as phenotype the percentages listed are estimated and will often times vary.
It should also be noted that if the THC percentage of oil or cannabis flowers being consumed is above 2% or equal to CBD content present, noticeable psychoactive effects may be felt.

Fortunately CBD also has anti-anxiety properties. High levels of it will help to reduce possible negative experiences from the effects of THC.

CBD may be ingested orally as well as vaporized.

If vaporization is used the vaporization temperature needs to be slightly higher than the temperatures used for vaporizing THC.

Edible forms of CBD may be the most effective way to consume CBD for fighting breast cancermetastasis.

 

If you are looking to start a CBD therapy, check out our Nature Going Shop. You can find organic, GMP-certified CBD products and much more.

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Finally, if you need help with dosage, do not hesitate to contact us at info@naturegoingsmart.com

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Copyright, Nature Going Smart. May not be re-printed without permission.

Viola Brugnatelli

Viola Brugnatelli is a Neuroscientist specialised in Cannabinoid circuitry & GPCRs signalling. Her academy and research training let her gain extensive experience on medical cannabis and terpenes both from preclinical as well as clinical perspective.
In her vision, collective human knowledge behold the power for overall improvement of life, thus, it should be accessible and shareable.
Viola is Founder of the science online magazine Nature Going Smart, and works as a consultant for companies & individual patients, as a speaker at seminars and workshops and as a lecturer in a CME course on Medical Cannabis in Italy, at the University of Padua.

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3 Responses

  1. maris says:

    A great testimony I must share to all cancer patients in the world. My husband was diagnosed with stage 4 primary liver cancer in
    March 2013. The doctor told us there was not much to be done since the tumor was 7 inches covering his lower lobe and also had
    spread to his lymph nodes. We decided to go home and called hospice which gave us morphine for pain. Ed hated the morphine which
    made him vomit and also affected his mind. After one week at home we decided to do what we have done for many years, rely on
    ourselves.We were only in Hospital for 3 days with severe Pain. The cancer had blocked his bile duct, after that we choose a
    Naturopath doctor and have not had conventional treatments. one day i came across the use of cannabis oil for treatment of cancer
    and i saw a post on how a cancer patient was cured with cannabis oil. I urgently needed help and i contacted to get the cannabis oil, i was given instructional guide on how to use it. After taking a gram of oil per day. Within a couple of weeks his pain and swollen stomach disappeared and with it came hope and a good quality of
    life. We never saw an ocologist and only have done a blood test after the first diagnose CT scan. His tumor marker went from over
    6000 to normal and he is feeling well. We don’t know how this is going to play out, but enjoy every day and give thanks. As i am
    writing this post, my husband is free from liver cancer and the doctor confirmed that the cancer was cured permanently.

  2. Susan Gunter says:

    My Father was diagnosed of brain cancer march 2015 and ever since then we have done chemotherapy 3 times but the cancer keep returning. Few months ago i heard about cannabis oil and its healing effect and i sourced the cannabis oil from Australia and my father began treatment immediately with the cannabis oil, after using the cannabis oil for treatment at the stipulated time prescribed, there was total cure and as i write now my father can walk around the house by himself without support from anybody and go out anytime he chooses.
    Regards,
    Susan Gunter

  3. Empeyjody says:

    Good day,
    This might be very helpful, I’m Empey Jody from Ozark, Missouri. Am using the medium to show my appreciation to Jackie Crowell who saved my grand momma’s life. My grand momma was diagnosed of lobular Breast cancer last year May 18th 2015; we had spent a lot on chemo. I never could understand how something so toxic as chemo could be use to get rid of cancer when it destroys goods cells as well. We have been sucked by this health challenge bothering grand momma, So i came across an article about Cannabis oil cures cancer first i did my research on it and a friend introduced us to Jackie Crowell who we purchased the oil from and he instructed us on how to use it (Dosage for Cannabis oil). Now my grand momma is living healthy all thanks to Jackie Crowell.

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