Noni vs Cancer: the Science

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Welcome to the second of a series of science insights on plants with medical properties that have been used traditionally for hundreds of years.

You can watch the first chapter on Morinda Citrifolia ,or as it is most commonly known “Noni” plant here: “The medical uses of Noni”.

We will review all the scientific evidences which have been carried out in recent years to understand the traditional uses of this plant and its mechanism of function for the treatment of various cancers.

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References:

Liu, Guangming, et al. “Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.” Cancer Research 61.15 (2001): 5749-5756.

Thani W, Vallisuta O, Siripong P, et al (2010). Anti-proliferative and antioxidative activities of Thai Noni/Yor (Morinda citrifolia Linn.) leaf extract. Southeast Asian J Trop Med Public Health, 41, 482-9.

Li J, Stickel SL, Bouton-Verville H, et al (2008). Fermented Noni Exudate (fNE): a mediator between immune system and antitumor activity. Oncol Reports, 20, 1505-9.

Furusawa E, Hirazumi A, Story S, et al (2003). Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytother Res, 17, 1158-64.

Hornick CA, Myers A, Sadowska-Krowicka H, et al (2003). Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (Noni). Angiogenesis, 6, 143-9.

Stoner GD, Wang LS, Seguin C, et al (2010). Multiple berry types 50.0 prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Pharm Res, 27, 1138-45.

Taşkin EI, Akgün-Dar K, Kapucu A, et al (2009). Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem 0 Funct, 27, 542-6.

Lv L, Chen H, Ho CT, et al (2011). Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects. Fitoterapia, 82, 704-8.

Gupta RK, Banerjee A, Pathak S, et al (2013). Induction of Mitochondrial-Mediated Apoptosis by Morinda citrifolia (Noni) in Human Cervical Cancer Cells. Asian Pac J Cancer Prev, 14, 237

 

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Viola Brugnatelli

Viola Brugnatelli is a Neuroscientist specialised in Cannabinoid circuitry & GPCRs signalling. Her academy and research training let her gain extensive experience on medical cannabis and terpenes both from preclinical as well as clinical perspective.
In her vision, collective human knowledge behold the power for overall improvement of life, thus, it should be accessible and shareable.
Viola is Founder of the science online magazine Nature Going Smart, and works as a consultant for companies & individual patients, as a speaker at seminars and workshops and as a lecturer in a CME course on Medical Cannabis in Italy, at the University of Padua.

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